CATH Domain 1ikqA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.200

Domain Context

CATH Clusters

Superfamily	2.60.120.200
Functional Family	Exotoxin A

Enzyme Information

2.4.2.36

NAD(+)--diphthamide ADP-ribosyltransferase.

based on mapping to UniProt P11439

NAD(+) + diphthamide-[translation elongation factor 2] = nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2].

-!- Dihtheria toxin and some other bacterial toxins catalyze this reaction, which inactivates translation elongation factor 2 (EF2). -!- The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. -!- Cf. EC 2.4.2.31. -!- The relevant histidine of EF2 is His(715) in mammals, His(699) in yeast and His(600) in Pyrococcus horikoshii.

UniProtKB Entries (1)

P11439

TOXA_PSEAE

Pseudomonas aeruginosa PAO1

Exotoxin A

PDB Structure

PDB	1IKQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Refined Crystallographic Structure of Pseudomonas aeruginosa Exotoxin A and its Implications for the Molecular Mechanism of Toxicity Wedekind, J.E., Trame, C.B., Dorywalska, M., Koehl, P., Raschke, T.M., McKee, M., FitzGerald, D., Collier, R.J., McKay, D.B. J.Mol.Biol.