CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.210 | Cytochrome C Oxidase; Chain A |
|
1.20.210.10 | Cytochrome c oxidase-like, subunit I domain |
Domain Context
CATH Clusters
| Superfamily | Cytochrome c oxidase-like, subunit I domain |
| Functional Family | Cytochrome o ubiquinol oxidase, subunit I |
Enzyme Information
| 7.1.1.3 |
Ubiquinol oxidase (H(+)-transporting).
based on mapping to UniProt P0ABI8
2 ubiquinol + O(2) + n H(+)(Side 1) = 2 ubiquinone + 2 H(2)O + n H(+)(Side 2).
-!- This terminal oxidase enzyme generates proton motive force by two mechanisms: (1) transmembrane charge separation resulting from utilizing protons and electrons originating from opposite sides of the membrane to generate water, and (2) active pumping of protons across the membrane. -!- The bioenergetic efficiency (the number of charges driven across the membrane per electron used to reduce oxygen to water) depends on the enzyme; for example, for the bo(3) oxidase it is 2, while for the bd-II oxidase it is 1. -!- Cf. EC 7.1.1.7. -!- Formerly EC 1.10.3.10.
|
UniProtKB Entries (1)
| P0ABJ3 |
CYOC_ECOLI
Escherichia coli K-12
Cytochrome bo(3) ubiquinol oxidase subunit 3
|
PDB Structure
| PDB | 1FFT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site.
Nat.Struct.Biol.
|
