CATH Classification

Domain Context

CATH Clusters

Superfamily Immunoglobulins
Functional Family Coagulation factor XIII A chain

Enzyme Information
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P00488
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

Homo sapiens
Coagulation factor XIII A chain

PDB Structure

PDB 1F13
External Links
Organism Saccharomyces
Primary Citation
Two non-proline cis peptide bonds may be important for factor XIII function.
Weiss, M.S., Metzner, H.J., Hilgenfeld, R.
FEBS Lett.