CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Dihydroorotate dehydrogenase

Enzyme Information
Dihydroorotate dehydrogenase (NAD(+)).
based on mapping to UniProt P54322
(S)-dihydroorotate + NAD(+) = orotate + NADH.
-!- The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit. -!- The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides. -!- Other class 1 dihydroorotate dehydrogenases use either fumarate (EC or NADP(+) (EC as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC uses quinone as electron acceptor.

UniProtKB Entries (1)

Lactococcus lactis subsp. cremoris MG1363
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit

PDB Structure

External Links
Organism Escherichia
Primary Citation
Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Rowland, P., Norager, S., Jensen, K.F., Larsen, S.
Structure Fold.Des.