CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Ribosomal RNA large subunit methyltransferase E

Enzyme Information

2.1.1.166
23S rRNA (uridine(2552)-2'-O)-methyltransferase.
based on mapping to UniProt P0C0R7
S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methyluridine(2552) in 23S rRNA.
-!- The enzyme catalyzes the 2'-O-methylation of the universally conserved U2552 in the A loop of 23S rRNA.

UniProtKB Entries (1)

P0C0R7
RLME_ECOLI
Escherichia coli K-12
Ribosomal RNA large subunit methyltransferase E

PDB Structure

PDB 1EJ0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
RNA methylation under heat shock control.
Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C., Jakob, U.
Mol.Cell