CATH Classification

Domain Context

CATH Clusters

Superfamily Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Functional Family Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

Enzyme Information

1.3.8.7
Medium-chain acyl-CoA dehydrogenase.
based on mapping to UniProt P11310
A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
-!- One of several enzymes that catalyze the first step in fatty acids beta-oxidation. -!- The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C(8) to C(12) compounds. -!- The enzyme from rat does not accept C(16) at all and is most active with C(6)-C(8) compounds. -!- cf. EC 1.3.8.1, EC 1.3.8.8 and EC 1.3.8.9. -!- Formerly EC 1.3.2.2 and EC 1.3.99.3.

UniProtKB Entries (1)

P11310
ACADM_HUMAN
Homo sapiens
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

PDB Structure

PDB 1EGD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the wild type and the Glu376Gly/Thr255Glu mutant of human medium-chain acyl-CoA dehydrogenase: influence of the location of the catalytic base on substrate specificity.
Lee, H.J., Wang, M., Paschke, R., Nandy, A., Ghisla, S., Kim, J.J.
Biochemistry