CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt P0A720
ATP + dTMP = ADP + dTDP.
2.7.4.9
dTMP kinase.
based on mapping to UniProt P23919
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (2)

P0A720
KTHY_ECOLI
Escherichia coli K-12
Thymidylate kinase
P23919
KTHY_HUMAN
Homo sapiens
Thymidylate kinase

PDB Structure

PDB 1E9F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
Ostermann, N., Lavie, A., Padiyar, S., Brundiers, R., Veit, T., Reintein, J., Goody, R.S., Konrad, M., Schlichting, I.
J.Mol.Biol.