CATH Classification
Domain Context
CATH Clusters
Superfamily | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 |
Functional Family |
Enzyme Information
1.5.1.28 |
Opine dehydrogenase.
based on mapping to UniProt Q44297
(2S)-2-((1-(R)-carboxyethyl)amino)pentanoate + NAD(+) + H(2)O = L-2- aminopentanoic acid + pyruvate + NADH.
-!- In the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. -!- Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. -!- In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. -!- They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. -!- The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate.
|
UniProtKB Entries (1)
Q44297 |
ODH_ARTSC
Arthrobacter sp. 1C
Opine dehydrogenase
|
PDB Structure
PDB | 1BG6 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase.
Nat.Struct.Biol.
|