CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P35235
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P35235
PTN11_MOUSE
Mus musculus
Tyrosine-protein phosphatase non-receptor type 11

PDB Structure

PDB 1AYD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase.
Lee, C.H., Kominos, D., Jacques, S., Margolis, B., Schlessinger, J., Shoelson, S.E., Kuriyan, J.
Structure