CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.10 | Ribbon |
|
2.10.25 | Laminin |
|
2.10.25.10 | Laminin |
Domain Context
CATH Clusters
| Superfamily | Laminin |
| Functional Family | Complement C1r subcomponent |
Enzyme Information
| 3.4.21.41 |
Complement subcomponent C1r.
based on mapping to UniProt P00736
Selective cleavage of Lys(or Arg)-|-Ile bond in complement subcomponent C1s to form the active form of C1s (EC 3.4.21.42).
-!- Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4. -!- Activated from proenzyme C1r in plasma by autocatalytic mechanism during activation of the complement system by the 'classical' route. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P00736 |
C1R_HUMAN
Homo sapiens
Complement C1r subcomponent
|
PDB Structure
| PDB | 1APQ |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family.
Biochemistry
|