CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.20 | Up-down Bundle | |
1.20.990 | NADPH-cytochrome p450 Reductase; Chain A, domain 3 | |
1.20.990.10 | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
Domain Context
CATH Clusters
Superfamily | NADPH-cytochrome p450 Reductase; Chain A, domain 3 |
Functional Family | NADPH--cytochrome P450 reductase |
Enzyme Information
1.6.2.4 |
NADPH--hemoprotein reductase.
based on mapping to UniProt P00388
NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.
-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.
|
UniProtKB Entries (1)
P00388 |
NCPR_RAT
Rattus norvegicus
NADPH--cytochrome P450 reductase
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PDB Structure
PDB | 1AMO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes.
Proc.Natl.Acad.Sci.USA
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