CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Adenylate cyclase

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P26769
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (1)

P26769
ADCY2_RAT
Rattus norvegicus
Adenylate cyclase type 2

PDB Structure

PDB 1AB8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the adenylyl cyclase catalytic core.
Zhang, G., Liu, Y., Ruoho, A.E., Hurley, J.H.
Nature