The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Cytochrome P450
".
FunFam 29452: Cytochrome P450 19A1
There are 9 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
Aromatase.
[EC: 1.14.14.14]
(1) Testosterone + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = 17-beta-estradiol + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase]. (2) Androst-4-ene-3,17-dione + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = estrone + formate + 4 H(2)O + 3 [oxidized NADPH--hemoprotein reductase].
|
26 |
A0A024R5S8
O42145
O46512
O73686
P11511
P19098
P22443
P28649
P46194
P70091 (16 more...) |
Prostaglandin-I synthase.
[EC: 5.3.99.4]
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate.
|
15 |
A9LLA5
F6YMG4
G1R5M7
G3HET1
H0X615
K7C397
O35074
Q16647
Q29626
Q62969 (5 more...) |
Unspecific monooxygenase.
[EC: 1.14.14.1]
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
|
12 |
A0A061IC63
A0A191Y1Z3
C9WPI9
K7N9Z5
K7NAC7
K7NAI8
K7NAJ2
Q45RG7
Q7T1M6
Q7T1M7 (2 more...) |
Cholesterol 7-alpha-monooxygenase.
[EC: 1.14.14.23]
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) = 7-alpha- hydroxycholesterol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
|
7 | A0A0B8RT12 O46491 P18125 P22680 P46634 P51542 Q64505 |
Transferred entry: 1.14.14.23.
[EC: 1.14.13.17]
|
3 | A0A140H636 A2QPL7 C1K3N8 |
25/26-hydroxycholesterol 7-alpha-hydroxylase.
[EC: 1.14.14.29]
(1) Cholest-5-ene-3-beta,25-diol + [reduced NADPH--hemoprotein reductase] + O(2) = cholest-5-ene-3-beta,7-alpha,25-triol + [oxidized NADPH- -hemoprotein reductase] + H(2)O. (2) (25R)-cholest-5-ene-3-beta,26-diol + [reduced NADPH--hemoprotein reductase] + O(2) = (25R)-cholest-5-ene-3-beta,7-alpha,26-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O.
|
3 | O75881 Q60991 Q63688 |
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase.
[EC: 1.14.18.8]
7-alpha-hydroxycholest-4-en-3-one + 2 ferrocytochrome b5 + 2 H(+) + O(2) = 7-alpha,12-alpha-dihydroxycholest-4-en-3-one + 2 ferricytochrome b5 + + H(2)O.
|
3 | O02766 O88962 Q9UNU6 |
Transferred entry: 1.14.18.8.
[EC: 1.14.13.95]
|
1 | G3H978 |
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase.
[EC: 1.14.13.96]
5-beta-cholestane-3-alpha,7-alpha-diol + NADPH + O(2) = 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol + NADP(+) + H(2)O.
|
1 | Q7YRB2 |