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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79359: Serine/threonine kinase family protein

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 2184 A0A023PAB1 A0A023PAB1 A0A045JXR2 A0A045JXR2 A0A049DQ77 A0A049DQ77 A0A059MK25 A0A059MK25 A0A059N2L6 A0A059N2L6
(2174 more...)
Mitogen-activated protein kinase kinase kinase. [EC: 2.7.11.25]
ATP + a protein = ADP + a phosphoprotein.
  • This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation.
  • Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras.
  • While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
 42 A0A059MK25 A0A059MK25 A0A0B9A652 A0A0B9A652 A0A0N0MM18 A0A0N0MM18 A0A0N0MTW4 A0A0N0MTW4 A0A0N0N3X5 A0A0N0N3X5
(32 more...)
Calcium/calmodulin-dependent protein kinase. [EC: 2.7.11.17]
ATP + a protein = ADP + a phosphoprotein.
  • Requires calmodulin.
  • A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein.
  • Not identical with EC EC 2.7.11.18 or EC 2.7.11.26.
  • Formerly EC 2.7.1.120 and EC 2.7.1.123.
 24 A0A0M1QNW7 A0A0M1QNW7 A0A0N1FJU2 A0A0N1FJU2 A0A150LRA6 A0A150LRA6 A0A178TY06 A0A178TY06 A0A1A9DTY1 A0A1A9DTY1
(14 more...)
Cyclin-dependent kinase. [EC: 2.7.11.22]
ATP + a protein = ADP + a phosphoprotein.
  • Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin.
  • It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
  • Formerly EC 2.7.1.37.
 10 A0A0R1JEW8 A0A0R1JEW8 F2JU59 F2JU59 F4FVA9 F4FVA9 F6B0H7 F6B0H7 F6BG74 F6BG74
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 8 A0A0S3QTF1 A0A0S3QTF1 A0A0S7YHK1 A0A0S7YHK1 A0A0S8FU35 A0A0S8FU35 A0A101EFZ1 A0A101EFZ1
Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
 6 A0A0L6JRW1 A0A0L6JRW1 A0A150FQW4 A0A150FQW4 F2NVH7 F2NVH7
Riboflavin synthase. [EC: 2.5.1.9]
2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D- ribitylamino)-5-amino-2,6-dihydroxypyrimidine.
    		 4 A0A0F4VNT9 A0A0F4VNT9 A0A0F4VSN6 A0A0F4VSN6
    Transferred entry: 2.7.11.1, 2.7.11.8, 2.7.11.9, 2.7.11.10, 2.7.11.11, 2.7.11.12, 2.7.11.13, 2.7.11.21, 2.7.11.22, 2.7.11.24, 2.7.11.25, 2.7.11.30 and 2.7.12.1. [EC: 2.7.1.37]
      		4 Q38XT3 Q38XT3 Q4JYC1 Q4JYC1
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