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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79025: Serine/threonine-protein kinase ULK2, putative

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 142 A0A061I6S9 A0A061I6S9 A0A0B0E8R3 A0A0B0E8R3 A0A0B2PFN8 A0A0B2PFN8 A0A0B2PKT9 A0A0B2PKT9 A0A0B2Q3K5 A0A0B2Q3K5
(132 more...)
[Myosin light-chain] kinase. [EC: 2.7.11.18]
ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.
  • Requires calmodulin for activity.
  • The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly.
  • Formerly EC 2.7.1.117.
 22 A0A074TU30 A0A074TU30 A0A086JX25 A0A086JX25 A0A086KY98 A0A086KY98 A0A086LIE0 A0A086LIE0 A0A086MBZ4 A0A086MBZ4
(12 more...)
Calcium/calmodulin-dependent protein kinase. [EC: 2.7.11.17]
ATP + a protein = ADP + a phosphoprotein.
  • Requires calmodulin.
  • A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein.
  • Not identical with EC EC 2.7.11.18 or EC 2.7.11.26.
  • Formerly EC 2.7.1.120 and EC 2.7.1.123.
 14 A0A0B2PFN8 A0A0B2PFN8 A0A0B2Q3K5 A0A0B2Q3K5 B9RMV5 B9RMV5 B9SV43 B9SV43 B9T0M6 B9T0M6
(4 more...)
Peptidylprolyl isomerase. [EC: 5.2.1.8]
Peptidylproline (omega=180) = peptidylproline (omega=0).
  • The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A.
  • Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli.
  • The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
 2 A0A0L1HTG8 A0A0L1HTG8
Poly(A)-specific ribonuclease. [EC: 3.1.13.4]
Exonucleolytic cleavage of poly(A) to 5'-AMP.
  • Cleaves poly(A) in either the single- or double-stranded form.
 2 G0R442 G0R442
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