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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 79007: Focal adhesion kinase 1

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
 1016 A0A023EZE8 A0A023EZE8 A0A024R7E4 A0A024R7E4 A0A024R7M7 A0A024R7M7 A0A060VVA2 A0A060VVA2 A0A060X1Z7 A0A060X1Z7
(1006 more...)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
  • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
  • Formerly EC 2.7.1.112.
 12 A0A0P5YUE4 A0A0P5YUE4 A0A0V1CP54 A0A0V1CP54 A0A0V1L4C1 A0A0V1L4C1 A0A1I7W0G2 A0A1I7W0G2 H2KZU7 H2KZU7
(2 more...)
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 8 O54967 O54967 Q07912 Q07912 Q17R13 Q17R13 Q5U2X5 Q5U2X5
Transferred entry: 2.7.10.1 and 2.7.10.2. [EC: 2.7.1.112]
    		4 O93597 O93597 Q7T2P8 Q7T2P8
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