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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 78964: G protein-coupled receptor kinase 1

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Rhodopsin kinase. [EC: 2.7.11.14]
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.
  • Acts on the bleached or activated form of rhodopsin.
  • Also phosphorylates the beta-adrenergic receptor, but more slowly.
  • Does not act on casein, histones or phosphovitin.
  • Inhibited by Zn(2+) and digitonin (cf. EC 2.7.11.15 and EC 2.7.11.16).
  • Formerly EC 2.7.1.97 and EC 2.7.1.125.
 158 A0A060X763 A0A060X763 A0A087XXT8 A0A087XXT8 A0A087YAS8 A0A087YAS8 A0A091EHR8 A0A091EHR8 A0A096P018 A0A096P018
(148 more...)
[G-protein-coupled receptor] kinase. [EC: 2.7.11.16]
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
  • All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate.
  • (cf. EC 2.7.11.14 and EC 2.7.11.15).
 36 A0A0B4KI69 A0A0B4KI69 E1JGX2 E1JGX2 O70291 O70291 O70293 O70293 P32298 P32298
(26 more...)
[Beta-adrenergic-receptor] kinase. [EC: 2.7.11.15]
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
  • Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly.
  • Does not act on casein or histones.
  • Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16).
  • Formerly EC 2.7.1.126.
 2 A0A061I4B4 A0A061I4B4