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CATH Superfamily 1.10.510.10

Transferase(Phosphotransferase) domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 78684: Casein kinase I delta

There are 10 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Non-specific serine/threonine protein kinase. [EC: 2.7.11.1]
ATP + a protein = ADP + a phosphoprotein.
  • This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date.
  • Formerly EC 2.7.1.37 and EC 2.7.1.70.
 520 A0A024R5W3 A0A024R5W3 A0A024W5F3 A0A024W5F3 A0A024WMS1 A0A024WMS1 A0A024X5E9 A0A024X5E9 A0A060RV95 A0A060RV95
(510 more...)
[Tau protein] kinase. [EC: 2.7.11.26]
ATP + [tau protein] = ADP + [tau protein] phosphate.
  • Activated by tubulin.
  • Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer's disease.
  • Formerly EC 2.7.1.135.
 26 A0A096NTN3 A0A096NTN3 A0A1A6GXU8 A0A1A6GXU8 F6QGF4 F6QGF4 G1RV86 G1RV86 G3QCX1 G3QCX1
(16 more...)
Non-specific protein-tyrosine kinase. [EC: 2.7.10.2]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain.
  • In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families.
  • Formerly EC 2.7.1.112.
 24 A0A074SRK7 A0A074SRK7 A0A086JM10 A0A086JM10 A0A086KE20 A0A086KE20 A0A086L9I1 A0A086L9I1 A0A086M1A2 A0A086M1A2
(14 more...)
Mitogen-activated protein kinase kinase kinase. [EC: 2.7.11.25]
ATP + a protein = ADP + a phosphoprotein.
  • This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, but requires MAPKKKK for activation.
  • Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras.
  • While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway.
  • Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation.
  • Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
  • Formerly EC 2.7.1.37.
 8 B7PRM1 B7PRM1 B7PYH7 B7PYH7 E0VUY0 E0VUY0 L1LCP3 L1LCP3
Dual-specificity kinase. [EC: 2.7.12.1]
ATP + a protein = ADP + a phosphoprotein.
  • This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
  • Formerly EC 2.7.1.37.
 4 B0E5X6 B0E5X6 B0E893 B0E893
[Myosin light-chain] kinase. [EC: 2.7.11.18]
ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.
  • Requires calmodulin for activity.
  • The 20 kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, more slowly.
  • Formerly EC 2.7.1.117.
 4 B0E8B5 B0E8B5 B0EBZ1 B0EBZ1
Poly(A)-specific ribonuclease. [EC: 3.1.13.4]
Exonucleolytic cleavage of poly(A) to 5'-AMP.
  • Cleaves poly(A) in either the single- or double-stranded form.
 2 G0QWZ7 G0QWZ7
1-phosphatidylinositol-3-phosphate 5-kinase. [EC: 2.7.1.150]
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 3,5-bisphosphate.
    		 2 G0QQT3 G0QQT3
    Palmitoyl-protein hydrolase. [EC: 3.1.2.22]
    Palmitoyl-[protein] + H(2)O = palmitate + [protein].
    • Specific for long-chain thioesters of fatty acids.
    • Hydrolyzes fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.
    		 2 G0QL50 G0QL50
    Glycylpeptide N-tetradecanoyltransferase. [EC: 2.3.1.97]
    Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
    • The enzyme from Saccharomyces cerevisiae is highly specific for tetradecanoyl-CoA, and for N-terminal glycine in oligopeptides containing serine in the 5-position.
    • The enzyme from mammalian heart transfers acyl groups to a specific acceptor protein of 51 kDa.
    		 2 A0A0D3A6I2 A0A0D3A6I2
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