CATH Domain 2jysA00

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Pro-Pol polyprotein

Enzyme Information

2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt P23074
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P23074 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.26.4	Ribonuclease H. based on mapping to UniProt P23074 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
3.1.-.-	Acting on ester bonds. based on mapping to UniProt P23074
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt P23074
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt P23074 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.

UniProtKB Entries (1)

POL_SFV1

Macaque simian foamy virus

Pro-Pol polyprotein

PDB Structure

PDB	2JYS
External Links	PDBSum Proteopedia
Method	SOLUTION NMR
Organism
Primary Citation	The solution structure of the simian foamy virus protease reveals a monomeric protein Hartl, M.J., Woehrl, B.M., Roesch, P., Schweimer, K. J.Mol.Biol.