CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cytochrome P450 family protein |
Enzyme Information
| 1.14.13.48 |
(S)-limonene 6-monooxygenase.
based on mapping to UniProt P11712
(-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O.
-!- High specificity, but NADH can act instead of NADPH, although more slowly.
|
| 1.14.13.- |
With NADH or NADPH as one donor, and incorporation of one atom of oxygen.
based on mapping to UniProt P11712
|
| 1.14.13.49 |
(S)-limonene 7-monooxygenase.
based on mapping to UniProt P11712
(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.
-!- High specificity, but NADH can act instead of NADPH, although more slowly.
|
| 1.14.99.38 |
Cholesterol 25-hydroxylase.
based on mapping to UniProt P11712
Cholesterol + AH(2) + O(2) = 25-hydroxycholesterol + A + H(2)O.
-!- Unlike most other sterol hydroxylases, this enzyme is not a cytochrome P450. -!- Instead, it uses diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. -!- The diiron cofactor can be either Fe-O-Fe or Fe-OH-Fe and is bound to the enzyme through interactions with clustered histidine or glutamate residues. -!- In cell cultures, this enzyme down-regulates cholesterol synthesis and the processing of sterol regulatory element binding proteins (SREBPs).
|
| 1.14.13.80 |
(R)-limonene 6-monooxygenase.
based on mapping to UniProt P11712
(+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O.
-!- The reaction is stereospecific with over 95% yield of (+)-trans- carveol from (R)-limonene. -!- (S)-Limonene, the substrate for EC 1.14.13.48 is not a substrate. -!- Forms part of the carvone biosynthesis pathway in Carum carvi (caraway) seeds.
|
UniProtKB Entries (1)
| P11712 |
CP2C9_HUMAN
Homo sapiens
Cytochrome P450 2C9
|
PDB Structure
| PDB | 1OG2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Human Cytochrome P450 2C9 with Bound Warfarin
Nature
|
