CATH Domain 1lw7A01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.620	HUPs

Domain Context

CATH Clusters

Superfamily	HUPs
Functional Family	Transcriptional regulator NadR, putative

Enzyme Information

2.7.7.1	Nicotinamide-nucleotide adenylyltransferase. based on mapping to UniProt P44308 ATP + nicotinamide ribonucleotide = diphosphate + NAD(+). -!- Nicotinate nucleotide can also act as acceptor. -!- See also EC 2.7.7.18.
2.7.1.22	Ribosylnicotinamide kinase. based on mapping to UniProt P44308 ATP + 1-(beta-D-ribofuranosyl)-nicotinamide = ADP + beta-nicotinamide D-ribonucleotide.

UniProtKB Entries (1)

NADR_HAEIN

Haemophilus influenzae Rd KW20

Bifunctional NAD biosynthesis protein NadR

PDB Structure

PDB	1LW7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of Haemophilus influenzae NadR protein. A bifunctional enzyme endowed with NMN adenyltransferase and ribosylnicotinimide kinase activities. Singh, S.K., Kurnasov, O.V., Chen, B., Robinson, H., Grishin, N.V., Osterman, A.L., Zhang, H. J.Biol.Chem.