CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.150 | DNA polymerase; domain 1 |
|
1.10.150.240 | Putative phosphatase; domain 2 |
Domain Context
CATH Clusters
| Superfamily | Putative phosphatase; domain 2 |
| Functional Family | Bifunctional phosphonoacetaldehyde hydrolase/aminoethylphosphonate transaminase |
Enzyme Information
| 3.11.1.1 |
Phosphonoacetaldehyde hydrolase.
based on mapping to UniProt O31156
Phosphonoacetaldehyde + H(2)O = acetaldehyde + phosphate.
-!- This enzyme destabilizes the C-P bond, by forming an imine between one of its lysine residues and the carbonyl group of the substrate, thus allowing this, normally stable, bond to be broken. -!- The mechanism is similar to that used by EC 4.1.2.13 to break a C-C bond.
|
UniProtKB Entries (1)
| O31156 |
PHNX_BACCE
Bacillus cereus
Phosphonoacetaldehyde hydrolase
|
PDB Structure
| PDB | 1FEZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of bacillus cereus phosphonoacetaldehyde hydrolase: insight into catalysis of phosphorus bond cleavage and catalytic diversification within the HAD enzyme superfamily.
Biochemistry
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