×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 3.30.450.40

GAF domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Phosphodiesterase
480 - - 79.3
3
GTP-sensing transcriptional pleiotropic repressor CodY
468
3D
 2hgvA00 - 88.4
2
IclR family transcriptional regulator
464 - - 47.9
4
Phosphodiesterase
420
3D
 2k31A00 - 87.7
5
Phosphodiesterase
337
3D
 2zmfB00 - 83.1
6
Phytochrome
331
3D
 4o0pB01 - 86.6
8
GAF domain-containing proteins
302
3D
 1vhmB00 - 86.3
7
Phosphodiesterase
288
3D
 1mc0A02 - 80.7
9
DNA-binding transcriptional regulator KdgR
283
3D
 1yspA00 - 91.7
10
Phosphodiesterase
240
3D
 3dbaB00 - 91.2
11
Phosphodiesterase
223 - - 75.2
12
Phosphoenolpyruvate-protein phosphotransferase PtsP
214 - - 54.2
13
Sensor histidine kinase YehU
202 - - 30.4
14
Phosphodiesterase
194
3D
 1mc0A01 - 76.4
15
Phosphodiesterase
194
3D
 3mf0B01 - 89.7
17
HTH-type transcriptional repressor AllR
186
3D
 1tf1D00 - 25.9
16
Heat-inducible transcription repressor HrcA
184 - - 59.0
18
Phosphodiesterase
175 - - 71.2
19
Heat-inducible transcription repressor HrcA
148 - - 58.7
20
Acetate operon transcriptional repressor IclR
147
3D
 2o9aD00 - 30.4
21
Anaerobic nitric oxide reductase transcription regulator NorR
143 - - 26.3
22
IclR family transcriptional regulator
139
3D
 1ysqA00 - 48.6
23
IclR family transcriptional regulator
136 - - 58.9
25
Stage V sporulation protein T
112
3D
 2w1rA00 - 34.5
24
Formate hydrogenlyase transcriptional activator
112 - - 20.7
26
Ethylene response sensor
108 - - 82.0
27
Sensor histidine kinase YpdA
103 - - 26.2
28
PAS domain S-box
96 - - 46.6
29
PAS domain S-box
94 - - 40.4
30
IclR family transcriptional regulator
92 - - 42.9
32
Phosphodiesterase
90 - - 84.4
31
Phosphodiesterase
90 - - 72.9
33
Transcriptional regulator, IclR family
87 - - 27.2
34
Sensor domain-containing diguanylate cyclase
85 - - 47.9
35
PAS sensor protein
76 - - 98.8
36
IclR family transcriptional regulator
63 - - 0.7
37
PAS sensor protein
61 - - 45.3
38
Two-component sensor histidine kinase KdpD
59
3D
 4y2fA00 - 60.1
39
IclR family transcriptional regulator
56 - - 77.3
40
Formate hydrogenlyase transcriptional activator
50 - - 3.0
52
Oxygen sensor histidine kinase response regulator DevS/DosS
43
3D
 2y8hB00 - 88.4
41
IclR family transcriptional regulator
42 - - 9.7
42
Probable diguanylate cyclase YeaP
38 - - 2.2
43
Phosphodiesterase
36 - - 35.3
44
Putative sensor histidine kinase/response regulator
33 - - 92.4
45
Heat-inducible transcription repressor HrcA
31 - - 3.7
48
Free methionine-R-sulfoxide reductase
30
3D
 3ko6B00 - 77.2
46
Phosphodiesterase
27 - - 31.6
47
IclR family transcriptional regulator
26 - - 38.3
49
Heat-inducible transcription repressor HrcA
25 - - 8.2
51
ABC1 family protein C21C3.03
23 - - 80.3
50
Transcriptional regulator, IclR family
23 - - 13.0
53
IclR family transcriptional regulator
21 - - 27.9
54
Diguanylate cyclase
GGDEF
21 - - 0.0
56
IclR family transcriptional regulator
20 - - 15.6
55
IclR family transcriptional regulator
20 - - 27.7
57
Two-component system sensor molecule
20 - - 79.6
58
GAF domain-containing protein
19 - - 0.8
77
PTS-dependent dihydroxyacetone kinase operon regulatory protein
19
3D
 4lrzH01 - 2.4
60
Stage II sporulation protein E
18 - - 12.8
59
IclR family transcriptional regulator
18 - - 25.4
62
Adenylate/guanylate cyclase catalytic domain protein
17 - - 2.3
61
Adenylate/guanylate cyclase catalytic domain protein
17 - - 0.0
63
Stage II sporulation protein E
17 - - 14.9
64
IclR family transcriptional regulator
16 - - 7.8
65
Hydrogenase-4 transcriptional activator
15 - - 3.9
66
Two-component system sensor histidine kinase KdpD
13 - - 24.3
67
Phosphodiesterase
13 - - 75.1
68
Diguanylate cyclase
GGDEF
13 - - 4.5
71
IclR family transcriptional regulator
12 - - 19.2
72
PAS domain-containing protein
12 - - 13.3
73
Stage II sporulation protein E
12 - - 0.8
70
Unplaced genomic scaffold supercont1.28, whole genome shotgun sequence
12 - - 18.6
69
Putative transcriptional regulator
12 - - 24.0
74
Phosphodiesterase
12 - - 23.1
80
Two component sensor histidine kinase
11 - - 32.0
76
IclR family transcriptional regulator
11 - - 0.0
75
Bifunctional diguanylate cyclase/phosphodiesterase
11 - - 0.0
79
Heat-inducible transcription repressor HrcA
11 - - 8.2
82
Sensor histidine kinase
11 - - 88.4
81
Vanadium nitrogenase sigma54-dependent transcriptional activator, VnfA
11 - - 93.3
78
Stage II sporulation protein E
11 - - 2.0
83
Sensor histidine kinase/response regulator, putative
AFU_orthologue AFUA_4G00660
11 - - 96.0
89
Sigma-54-dependent Fis family transcriptional regulator
10 - - 18.9
87
Phosphoserine phosphatase RsbP
10 - - 18.4
84
IclR family transcriptional regulator
10 - - 40.3
88
Heat-inducible transcription repressor HrcA
10 - - 17.1
85
PAS/PAC sensor protein
10 - - 23.5
86
Phosphatase
10 - - 19.7
92
Crp family transcriptional regulator
9 - - 0.0
91
IclR family transcriptional regulator
9 - - 29.2
93
IclR family transcriptional regulator
9 - - 2.0
90
Putative transcriptional regulator
9 - - 16.4
94
dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like
9 - - 33.1
96
IclR family transcriptional regulator
8 - - 9.4
95
Transcriptional regulator, IclR family
8 - - 19.1
97
Two-component sensor histidine kinase
8 - - 12.2
147
Heat-inducible transcription repressor HrcA
7
3D
 1stzC02 - 18.4
101
Sigma-54 dependent transcriptional regulator
7 - - 0.0
100
GAF modulated transcriptional regulator, LuxR family
7 - - 18.9
99
Sensor histidine kinase, KdpD
7 - - 0.0
98
IclR family transcriptional regulator
7 - - 10.3
108
GAF domain-containing protein
6 - - 70.2
105
Transcriptional regulator, IclR family
6 - - 13.1
107
Sensor histidine kinase KdpD
6 - - 5.9
111
IclR family transcriptional regulator
6 - - 22.0
102
Phosphatase
6 - - 17.5
113
Histidine kinase
6 - - 28.3
110
Histidine kinase sensor protein
6 - - 5.2
104
IclR family transcriptional regulator
6 - - 0.0
109
Stage II sporulation protein E
6 - - 0.0
106
Transcriptional regulatory protein
6 - - 16.4
112
Heat-inducible transcription repressor HrcA
6 - - 1.9
103
Transcriptional regulatory protein
6 - - 15.1
143
Phosphodiesterase
6
3D
 3mf0A01 - 26.9
155
Bacteriophytochrome protein
6
3D
 5i5lA01 - 15.1
116
IclR family transcriptional regulator
5 - - 1.5
123
Sigma-54-dependent Fis family transcriptional regulator
5 - - 0.0
121
Serine/threonine protein phosphatase
5 - - 7.8
120
Sensory transduction histidine kinase
5 - - 92.7
122
Phytochrome-like protein
5 - - 2.8
124
Sigma-54 dependent transcriptional regulator
5 - - 0.0
114
IclR family transcriptional regulator
5 - - 16.6
119
Two-component sensor KdpD
5 - - 0.0
140
PelD
5
3D
 4etxA01 - 1.5
118
Diguanylate cyclase-related enzyme
5 - - 0.0
115
Transcriptional regulator, IclR family
5 - - 0.0
117
Diguanylate cyclase-related enzyme
5 - - 0.0
142
Histidine kinase
4 - - 5.8
219
Phytochrome-like protein cph2
4
3D
 4bwiB01 - 0.6
144
Phytochrome
4 - - 6.6
130
Transcriptional regulatory protein
4 - - 7.4
126
Serine/threonine-protein phosphatase
4 - - 13.0
131
Transcriptional regulatory protein
4 - - 4.3
136
Phosphodiesterase
4 - - 29.9
148
Heat-inducible transcription repressor HrcA
4 - - 3.4
145
Protein serine phosphatase with GAF
S S
4 - - 5.7
133
IclR family transcriptional regulator
4 - - 5.0
139
Histidine kinase
4 - - 11.0
134
Transcriptional regulatory protein
4 - - 7.8
129
Transcriptional regulator
4 - - 3.4
132
Transcriptional regulatory protein
4 - - 8.7
191
Bacteriophytochrome
Light-regulated signal transduction histidine kinase
4
3D
 4r70B01 - 1.4
146
Stage II sporulation protein E
4 - - 0.0
141
Adenylate cyclase
4 - - 9.0
138
Phosphodiesterase
4 - - 69.6
135
Bacteriophytochrome
4 - - 0.0
209
Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing
4
3D
 3eeaB00 - 0.0
137
Sensory transduction histidine kinase
4 - - 43.7
127
Sigma factor sigB regulation protein rsbU
4 - - 12.7
125
Transcriptional regulator, IclR family
4 - - 7.2
128
Helix-turn-helix transcriptional regulator, IclR family
4 - - 26.5
149
IclR family transcriptional regulator
3 - - 1.7
163
PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase
3 - - 0.0
153
Transcriptional regulator
3 - - 9.6
166
GGDEF family protein
3 - - 0.0
161
Sensor histidine kinase/response regulator, putative
3 - - 0.0
156
Sensory transduction histidine kinase
3 - - 19.5
151
IclR family transcriptional regulator
3 - - 0.0
150
Hybrid sensory kinase
3 - - 5.7
160
Sensory transduction histidine kinase
3 - - 0.0
152
IclR family transcriptional regulator
3 - - 12.2
162
Diguanylate cyclase/phosphodiesterase
GGDEF & EAL domains S
3 - - 6.5
159
Two-component system sensor histidine kinase/response regulator
3 - - 11.3
154
Heat-inducible transcription repressor HrcA
3 - - 5.8
164
GAF sensor signal transduction histidine kinase
3 - - 13.3
169
PAS sensor protein
3 - - 0.0
165
Heat-inducible transcription repressor HrcA
3 - - 0.0
170
Phosphodiesterase
3 - - 36.2
157
Histidine kinase osmosensor and regulator, putative
3 - - 8.2
167
Diguanylate cyclase
3 - - 4.0
158
Stage II sporulation E family protein
3 - - 5.8
168
Histidine kinase
3 - - 8.5
184
Transcriptional regulator
2 - - 3.2
229
GAF domain-containing protein
2 - - 0.0
172
Sigma factor SibG regulation protein RsbU
2 - - 0.0
197
Polyketide synthase
2 - - 0.0
224
Two-component signal transduction
2 - - 5.9
189
ATP-binding region ATPase domain protein
2 - - 0.0
200
GAF domain-containing protein
2 - - 0.0
232
Heat-inducible transcription repressor HrcA
2 - - 8.4
195
Two-component hybrid sensor and regulator
2 - - 43.1
198
PAS sensor protein
2 - - 39.2
214
Guanylate cyclase
2 - - 0.0
201
Histidine kinase
2 - - 11.0
206
GAF domain-containing protein
2 - - 0.0
212
GAF domain protein
2 - - 0.0
174
Uncharacterized protein
2 - - 8.5
182
IclR family transcriptional regulator
2 - - 7.7
179
IclR family transcriptional regulator
2 - - 0.0
222
GAF domain-containing protein
2 - - 0.0
203
Adenylyl cyclase class-3/4/guanylyl cyclase
2 - - 0.0
239
Sensor histidine kinase, GAF domain-containing
2 - - 0.0
234
Sensor domain-containing diguanylate cyclase
2 - - 0.0
199
Stage II sporulation E family protein
2 - - 0.0
187
GAF sensor signal transduction histidine kinase
2 - - 7.9
227
PAS domain-containing protein
2 - - 0.0
194
Uncharacterized protein
2 - - 8.8
185
GGDEF domain-containing protein
2 - - 0.0
240
Sensor histidine kinase, GAF domain-containing
2 - - 0.0
225
PAS sensor protein
2 - - 0.0
218
Slr1385 protein
2 - - 0.0
215
PleD gene product
2 - - 0.0
228
Sensor histidine kinase, PAS and GAF domain-containing
2 - - 0.0
188
GAF domain-containing protein
2 - - 0.0
217
PleD gene product
2 - - 0.0
246
Sensory transduction histidine kinase
2 - - 38.4
241
Phosphodiesterase
2 - - 37.5
178
IclR family transcriptional regulator
2 - - 0.0
238
PleD
2 - - 0.0
177
Probable HTH-type transcriptional regulator ArcR
2 - - 0.0
192
Uncharacterized protein
2 - - 18.6
235
Diguanylate cyclase with GAF sensory domain
2 - - 12.8
243
Phosphodiesterase
2 - - 39.2
175
Regulator of polyketide synthase expression
2 - - 0.0
237
GGDEF family protein
2 - - 1.4
208
PAS sensor protein
2 - - 0.0
205
Stage II sporulation E family protein
2 - - 0.0
190
ATP-binding region ATPase domain protein
2 - - 0.0
207
Stage II sporulation E family protein
2 - - 0.0
244
Phosphodiesterase
2 - - 13.0
249
Phosphodiesterase
2 - - 38.2
242
Phosphodiesterase
2 - - 40.3
193
GAF domain-like protein
2 - - 0.0
196
Histidine kinase dimerisation and phosphoacceptor region
2 - - 40.7
231
Heat-inducible transcription repressor HrcA
2 - - 0.0
236
Sensor diguanylate cyclase, GAF domain-containing
2 - - 0.0
210
Sodium/solute symporter, GAF and PP2C family protein serine/threonine phosphatase domain protein
2 - - 0.0
248
Two component signal transduction system histidine kinase with GAF sensory domain
2 - - 40.5
171
Stage II sporulation E family protein
2 - - 0.0
176
Transcriptional regulator, IclR family
2 - - 38.6
233
Heat-inducible transcription repressor HrcA
2 - - 5.8
245
Phosphodiesterase
2 - - 0.0
180
IclR family transcriptional regulator
2 - - 0.0
220
Phytochrome-like protein cph1
2 - - 0.0
247
Phosphodiesterase
2 - - 42.8
204
GAF sensor methyl-accepting chemotaxis sensory transducer, class 40H
2 - - 0.0
173
Phosphoenolpyruvate-protein phosphotransferase
2 - - 0.0
216
Pca regulon regulatory protein
2 - - 0.0
211
Histidine kinase
2 - - 0.0
223
Pca regulon regulatory protein
2 - - 0.0
202
Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing
2 - - 0.0
183
IclR family transcriptional regulator
2 - - 7.0
230
Heat-inducible transcription repressor HrcA
2 - - 0.0
213
Uncharacterized protein
2 - - 0.0
226
Serine phosphatase RsbU, regulator of sigma subunit
2 - - 1.3
221
Phytochrome-like protein cph2
2 - - 0.0
181
IclR family transcriptional regulator
2 - - 0.0
186
Diguanylate cyclase
2 - - 0.0
259
Transcriptional regulatory protein
1 - - 0.0
307
Phosphodiesterase
1 - - 0.0
254
GAF domain phosphoenolpyruvate--protein phosphotransferase PtsP
1 - - 0.0
293
PAS sensor protein
1 - - 0.0
264
Chromosome 21, whole genome shotgun sequence
1 - - 0.0
305
Putative signaling protein
1 - - 0.0
269
Histidine kinase dimerisation and phosphoacceptor region
1 - - 0.0
308
Phosphodiesterase
1 - - 0.0
291
cGMP-specific 3',5'-cyclic phosphodiesterase
1 - - 0.0
296
Histidine kinase
1 - - 0.0
252
Uncharacterized protein
1 - - 0.0
290
Phosphodiesterase
1 - - 0.0
262
Chromosome 21, whole genome shotgun sequence
1 - - 0.0
265
Uncharacterized protein
1 - - 0.0
270
PAS sensor protein
1 - - 0.0
309
Phosphodiesterase
1 - - 0.0
257
Transcriptional regulator
1 - - 0.0
304
Sensory box/ggdef domain protein
1 - - 0.0
267
AGAP012811-PA
1 - - 0.0
283
Phosphodiesterase
1 - - 0.0
255
Sensor histidine kinase, GAF domain-containing
1 - - 0.0
258
Probable transcriptional regulator
1 - - 0.0
310
Phosphodiesterase
1 - - 0.0
268
Uncharacterized protein
1 - - 0.0
281
Phosphodiesterase
1 - - 0.0
286
Phosphodiesterase
1 - - 0.0
313
Phosphodiesterase
1 - - 0.0
271
Histidine kinase
1 - - 0.0
276
Receptor-like histidine kinase BpdS
1 - - 0.0
280
Phosphodiesterase
1 - - 0.0
302
Two-component hybrid sensor and regulator
1 - - 0.0
311
Phosphodiesterase
1 - - 0.0
273
Sensory transduction histidine kinase
1 - - 0.0
282
Phosphodiesterase
1 - - 0.0
274
Histidine kinase
1 - - 0.0
279
Two-component response regulator
1 - - 0.0
300
Uncharacterized protein
1 - - 0.0
272
PAS sensor protein
1 - - 0.0
284
Phosphodiesterase
1 - - 0.0
289
Phosphodiesterase
1 - - 0.0
297
Sensor histidine kinase, PAS and GAF domain-containing
1 - - 0.0
303
Heat-inducible transcription repressor HrcA
1 - - 0.0
295
Acetoin catabolism regulatory protein
1 - - 0.0
298
Glr3986 protein
1 - - 0.0
312
Phosphodiesterase 11a,-like
1 - - 0.0
306
Phosphodiesterase
1 - - 0.0
301
PAS sensor protein
1 - - 0.0
278
Diguanylate cyclase with PAS/PAC sensor
1 - - 0.0
277
Phosphodiesterase
1 - - 0.0
250
Uncharacterized protein
1 - - 0.0
292
Phosphodiesterase
1 - - 0.0
260
Probable IclR family regulator
Putative secreted protein
1 - - 0.0
275
Uncharacterized protein
1 - - 0.0
287
Phosphodiesterase
1 - - 0.0
299
PAS sensor protein
1 - - 0.0
294
PAS sensor protein
1 - - 0.0
263
Uncharacterized protein
1 - - 0.0
253
Uncharacterized protein
1 - - 0.0
285
Sensory transduction histidine kinase
1 - - 0.0
266
Osmosensitive potassium channel sensor histidine kinase KdpD, KdpD and USP_OKCHK domain-containing
1 - - 0.0
261
Heat-inducible transcription repressor HrcA
1 - - 0.0
288
Uncharacterized protein
1 - - 0.0
256
Transcriptional regulator
IclR family
1 - - 0.0
251
Uncharacterized protein
1 - - 0.0
CATH-Gene3D is a Global Biodata Core Resource Learn more...