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CATH Superfamily 1.10.555.10

Rho GTPase activation protein

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Rho GTPase activation protein
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
Rho GTPase activating protein 44
832 - - 93.5
2
rho GTPase-activating protein 32 isoform X1
674
3D
 3iugB00 - 83.4
3
Putative rho GTPase-activating protein 12
617
3D
 3byiD00 - 86.8
4
active breakpoint cluster region-related protein-like
484 - - 81.3
5
Chimaerin
469
3D
 3cxlA03 - 87.1
6
Rho GTPase activating protein 26
435
3D
 1f7cA00 - 90.1
7
rho GTPase-activating protein 7 isoform X2
415
3D
 3kuqA00 - 71.3
8
Rho GTPase-activating protein 42
370 - - 81.1
9
unconventional myosin-IXa isoform X1
348
3D
 5hpyD00 - 68.3
10
SLIT-ROBO Rho GTPase-activating protein 1 isoform 2
323 - - 82.8
11
Rho GTPase-activating protein 39
305 - - 81.2
12
Putative inositol polyphosphate 5-phosphatase OCRL-1
281
3D
 3qisA02 - 94.2
13
SLIT-ROBO Rho GTPase activating protein 3
278 - - 68.4
14
Rho GTPase activating protein 21
256 - - 85.0
15
rho GTPase-activating protein 25 isoform X1
255 - - 81.4
16
Rho GTPase activating protein 29
234 - - 74.1
17
Rho GTPase activating protein 6
230 - - 79.6
18
Rho GTPase activating protein 28
218 - - 92.1
19
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
214
3D
 5jcpB01 - 77.0
21
rho GTPase-activating protein 5
204
3D
 3fk2D00 - 70.6
20
protein FAM13B isoform X1
204 - - 33.2
22
rho GTPase-activating protein 19
172 - - 70.4
24
Rho GTPase-activating protein 1
163
3D
 6r3vA00 - 80.2
23
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
159 - - 48.5
25
Rho GTPase-activating protein 20
150
3D
 3msxB00 - 89.7
26
Rho GTPase activating protein 4
141 - - 89.8
27
RalA-binding protein 1
137
3D
 2mbgA01 - 91.0
28
rho GTPase-activating protein 18 isoform X1
131 - - 70.9
29
DEP domain-containing protein 1B isoform X2
131 - - 77.0
30
rho GTPase-activating protein 9 isoform X1
97 - - 77.7
31
rho GTPase-activating protein 100F isoform X6
96 - - 81.6
34
Rac GTPase-activating protein 1
93
3D
 5c2jA00 - 85.2
32
Uncharacterized protein, isoform E
91 - - 76.3
33
Rho GTPase activator
Lrg11
88 - - 73.5
35
Phosphatidylinositol 3-kinase regulatory subunit alpha
88
3D
 1pbwB00 - 85.1
36
T-cell activation Rho GTPase-activating protein
70 - - 80.6
37
Phosphatidylinositol 3-kinase regulatory subunit beta
70
3D
 2xs6A00 - 81.8
38
DEP domain-containing protein 1A isoform X1
64 - - 62.6
39
N-chimaerin isoform X5
60 - - 89.6
40
Family with sequence similarity 13 member A
55 - - 26.2
41
Rho GTPase activator
Rgd1
54 - - 53.0
42
rho GTPase-activating protein 11A isoform X1
54
3D
 3eapD00 - 43.5
43
Rho GTPase activator Rga
46 - - 87.1
44
Rho-gtpase-activating protein 8
41 - - 80.0
45
RhoGAP domain containing protein
35 - - 98.1
47
rho GTPase-activating protein 190 isoform X3
30 - - 8.0
46
Rho GTPase-activating protein 5
30 - - 63.2
48
CHN2 isoform 6
26 - - 10.1
49
Related to BEM3-GTPase-activating protein
26 - - 71.2
50
GTPase-activating protein
25 - - 78.8
52
Rho GTPase-activating protein REN1
25 - - 47.8
51
Synapse defective Rho GTPase homolog 1
25 - - 53.0
53
RhoGAP domain containing protein
24 - - 81.0
55
Similar to GTPase-activating protein testicular GAP1
21 - - 87.6
54
Uncharacterized protein, isoform B
21 - - 18.6
56
AGAP001687-PB
20 - - 79.0
57
Rho GTPase-activating protein
20 - - 80.0
58
GTPase-activating protein pac-1
19 - - 84.9
59
rho GTPase-activating protein 30 isoform X2
17 - - 40.8
61
Rho GTPase activating protein 9
17 - - 5.2
60
Rho-GTPase-activating protein RGD2
17 - - 71.1
63
Lrg1p
16 - - 71.8
62
Uncharacterized protein, isoform B
16 - - 17.0
64
Rho GTPase activating protein at 15B, isoform B
16 - - 13.0
65
Rho GTPase activator, putative
15 - - 15.8
66
Rho GTPase activator
Bem3
15 - - 53.3
72
Protein RGD1
14
3D
 5my3A00 - 29.0
67
Rho GTPase-activating protein conundrum
14 - - 79.4
68
RhoGAP domain containing protein
13 - - 86.1
71
Rho GTPase activating protein 27
13 - - 80.7
69
Rho GTPase Activating protein
13 - - 92.1
70
Phosphatidylinositol 3-kinase regulatory subunit alpha-like Protein
13 - - 74.3
73
SLIT-ROBO Rho GTPase-activating protein 2
12 - - 51.5
74
RhoGAP GTPase, putative
12 - - 11.6
75
Rho GTPase-activating protein
12 - - 30.8
76
Rho GTPase-activating protein
11 - - 29.4
77
GTPase activating protein
10 - - 84.9
78
RhoGAP domain containing protein
9 - - 29.9
81
Rho GTPase Activating protein
9 - - 23.5
79
YHR182W-like protein
9 - - 0.0
80
Similar to GTPase-activating protein testicular GAP1
9 - - 73.3
83
Rho GTPase Activating protein
8 - - 15.6
86
Heavy chain, Unconventional Myosin
8 - - 13.7
85
Rho GTPase-activating protein-like protein
8 - - 48.6
82
Rho GTPase activating protein, putative
8 - - 4.6
84
WW domain-containing protein tag-325
8 - - 24.0
87
RalA-binding protein 1
8 - - 44.1
98
Related to BEM2-GTPase-activating protein
7 - - 17.2
88
RhoGAP domain containing protein
7 - - 3.0
93
RhoGAP domain containing protein
7 - - 9.6
95
RhoGAP domain containing protein
7 - - 5.1
92
RhoGAP domain containing protein
7 - - 5.4
96
Chromosome 1, whole genome shotgun sequence
7 - - 9.9
97
CYtoKinesis defect
7 - - 12.9
94
RhoGAP domain containing protein
7 - - 10.7
91
Rho GTPase activating protein, putative
7 - - 4.7
99
T-cell activation Rho GTPase activating protein, putative
7 - - 8.3
100
Inositol polyphosphate 5-phosphatase, putative
7 - - 4.5
89
Rho GTPase activating protein, putative
7 - - 3.2
101
Oligophrenin 1
7 - - 58.3
90
T-cell activation Rho GTPase activating protein, putative
7 - - 5.3
104
RhoGAP domain containing protein
6 - - 0.0
102
Rho GTPase activating protein, putative
6 - - 2.6
108
Rho GTPase Activating protein
6 - - 60.9
107
Type II inositol-1,4,5-trisphosphate 5-phosphatase, putative
6 - - 0.0
105
Mental retardation GTPase activating protein homolog 2
6 - - 80.4
106
Ecm25p
6 - - 1.3
103
RhoGAP domain containing protein
6 - - 3.6
118
Rho GTPase activating protein 28
5 - - 55.0
110
RhoGAP domain containing protein
5 - - 2.5
109
Rho GTPase-activating protein 19
5 - - 82.0
117
LIM and Rho-GAP domain-containing protein
5 - - 1.5
115
CHImaeriN
Rac-GTPase-activating protein
5 - - 13.2
111
RhoGAP domain containing protein
5 - - 8.7
116
EG:86E4.5 protein
5 - - 11.6
113
Glucosamine 6-phosphate N-acetyltransferase
5 - - 5.4
114
RhoGAP domain containing protein
5 - - 0.6
112
SLIT-ROBO Rho GTPase-activating protein 3
5 - - 79.1
125
Protein CBR-OCRL-1
4 - - 10.6
127
Rho GTPase activating protein 39
4 - - 14.2
131
Chromosome 16, whole genome shotgun sequence
4 - - 81.0
120
Rho GTPase-activating protein gacN
4 - - 63.9
128
Rho GTPase-activating protein 39
4 - - 69.2
133
4 - - 77.3
130
4 - - 74.5
123
Rho GTPase activating protein putative
4 - - 0.0
121
Rho GTPase-activating protein gacJ
4 - - 67.4
126
Uncharacterized protein
4 - - 2.2
132
Inositol polyphosphate-5-phosphatase B
4 - - 69.1
124
Phosphoinositide-3-kinase, regulatory subunit 2
beta
4 - - 30.4
129
Uncharacterized protein
4 - - 75.4
119
Rho GTPase-activating protein 33
4 - - 60.2
134
SLIT-ROBO Rho GTPase-activating protein 2
4 - - 22.5
122
Rho GTPase Activating protein
4 - - 27.8
140
GTPase-activating protein rrc-1
3 - - 17.5
136
T-cell activation GTPase activating protein
3 - - 0.0
147
3 - - 4.9
145
3 - - 16.6
138
Uncharacterized protein
3 - - 0.0
141
Rho GTPase-activating protein
RhoGAP
3 - - 5.7
146
Similar to rho-type GTPase-activating protein
3 - - 14.5
137
rho GTPase-activating protein 18 isoform X2
3 - - 0.4
143
Uncharacterized protein
3 - - 9.3
135
Rho GTPase-activating protein 18
3 - - 6.7
144
inositol polyphosphate 5-phosphatase OCRL-1 isoform X3
3 - - 0.7
142
YALI0A17578p
3 - - 0.0
139
Probable inactive serine/threonine-protein kinase DDB_G0293184
3 - - 50.3
155
2 - - 0.0
183
2 - - 31.4
148
2 - - 40.1
167
2 - - 2.9
178
2 - - 0.0
157
Uncharacterized protein
2 - - 0.0
170
2 - - 0.0
165
2 - - 0.0
186
2 - - 39.7
181
Uncharacterized protein
2 - - 0.4
168
2 - - 39.9
175
2 - - 0.0
160
2 - - 11.9
150
2 - - 18.7
158
YALI0A12111p
2 - - 0.0
177
2 - - 0.0
176
2 - - 0.5
171
2 - - 0.6
185
2 - - 38.5
153
2 - - 1.4
163
Rgd1p
2 - - 0.0
187
2 - - 22.4
173
2 - - 8.4
151
2 - - 25.3
156
2 - - 7.4
161
2 - - 18.9
166
2 - - 8.2
180
2 - - 0.0
169
Probable inactive serine/threonine-protein kinase roco10
2 - - 19.0
164
2 - - 1.5
154
2 - - 1.8
159
T cell activation RhoGTPase-activating protein a
2 - - 0.0
149
2 - - 19.8
179
2 - - 2.9
174
YALI0E07601p
2 - - 0.0
182
2 - - 0.0
184
2 - - 41.6
172
2 - - 0.0
162
Mental retardation GTPase activating protein homolog 1
2 - - 27.0
152
2 - - 8.9
271
1 - - 0.0
230
1 - - 0.0
202
1 - - 0.0
223
1 - - 0.0
253
1 - - 0.0
238
1 - - 0.0
263
1 - - 0.0
211
1 - - 0.0
216
1 - - 0.0
241
1 - - 0.0
246
1 - - 0.0
237
1 - - 0.0
221
1 - - 0.0
226
1 - - 0.0
251
1 - - 0.0
256
1 - - 0.0
213
1 - - 0.0
235
1 - - 0.0
192
1 - - 0.0
261
1 - - 0.0
266
1 - - 0.0
243
1 - - 0.0
248
1 - - 0.0
225
1 - - 0.0
255
1 - - 0.0
218
1 - - 0.0
240
1 - - 0.0
267
1 - - 0.0
210
1 - - 0.0
257
1 - - 0.0
194
1 - - 0.0
227
1 - - 0.0
236
1 - - 0.0
270
1 - - 0.0
199
1 - - 0.0
231
1 - - 0.0
265
1 - - 0.0
209
1 - - 0.0
268
1 - - 0.0
247
1 - - 0.0
217
1 - - 0.0
204
1 - - 0.0
260
1 - - 0.0
250
1 - - 0.0
220
1 - - 0.0
188
1 - - 0.0
258
1 - - 0.0
233
1 - - 0.0
215
1 - - 0.0
245
1 - - 0.0
228
1 - - 0.0
242
1 - - 0.0
212
1 - - 0.0
193
1 - - 0.0
206
1 - - 0.0
201
1 - - 0.0
234
1 - - 0.0
196
1 - - 0.0
239
1 - - 0.0
191
1 - - 0.0
262
1 - - 0.0
252
1 - - 0.0
203
1 - - 0.0
222
1 - - 0.0
208
1 - - 0.0
232
1 - - 0.0
195
1 - - 0.0
269
1 - - 0.0
264
1 - - 0.0
200
1 - - 0.0
224
1 - - 0.0
197
1 - - 0.0
189
1 - - 0.0
254
1 - - 0.0
259
1 - - 0.0
229
1 - - 0.0
249
1 - - 0.0
219
1 - - 0.0
207
1 - - 0.0
214
1 - - 0.0
244
1 - - 0.0
190
1 - - 0.0
198
1 - - 0.0
205
1 - - 0.0
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