CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P0A7Z6
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (2)

Q0P6L9
Q0P6L9_ECOLX
Escherichia coli
RNA polymerase sigma factor RpoD
P0A7Z6
RPOA_ECO57
Escherichia coli O157:H7
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 6N62
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin.
Braffman, N.R., Piscotta, F.J., Hauver, J., Campbell, E.A., Link, A.J., Darst, S.A.
Proc. Natl. Acad. Sci. U.S.A.