1 keywords

CATH Domain 6fbvA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1360 Gyrase A; domain 2
Homologous Superfamily 3.30.1360.10 RNA polymerase, RBP11-like subunit

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family DNA-directed RNA polymerase subunit alpha

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P9WGZ1
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P9WGI1
SIGA_MYCTU
Mycobacterium tuberculosis H37Rv
RNA polymerase sigma factor SigA

PDB Structure

PDB 6FBV
External Links
Method ELECTRON MICROSCOPY
Organism
Primary Citation
Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3).
Lin, W., Das, K., Degen, D., Mazumder, A., Duchi, D., Wang, D., Ebright, Y.W., Ebright, R.Y., Sineva, E., Gigliotti, M., Srivastava, A., Mandal, S., Jiang, Y., Liu, Y., Yin, R., Zhang, Z., Eng, E.T., Thomas, D., Donadio, S., Zhang, H., Zhang, C., Kapanidis, A.N., Ebright, R.H.
Mol. Cell