CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.65
Macrophage elastase.
based on mapping to UniProt P39900
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.
-!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P39900
MMP12_HUMAN
Homo sapiens
Macrophage metalloelastase

PDB Structure

PDB 6EKN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies.
Nuti, E., Cuffaro, D., Bernardini, E., Camodeca, C., Panelli, L., Chaves, S., Ciccone, L., Tepshi, L., Vera, L., Orlandini, E., Nencetti, S., Stura, E.A., Santos, M.A., Dive, V., Rossello, A.
J. Med. Chem.