CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family |
Enzyme Information
| 2.1.1.128 |
(RS)-norcoclaurine 6-O-methyltransferase.
based on mapping to UniProt Q5C9L7
S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine.
-!- The enzyme will also catalyze the 6-O-methylation of (RS)- norlaudanosoline to form 6-O-methyl-norlaudanosoline, but this alkaloid has not been found to occur in plants.
|
UniProtKB Entries (1)
| Q5C9L7 |
6OMT_THLFG
Thalictrum flavum subsp. glaucum
(RS)-norcoclaurine 6-O-methyltransferase
|
PDB Structure
| PDB | 5ICF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of norcoclaurine-6-O-methyltransferase, a key rate-limiting step in the synthesis of benzylisoquinoline alkaloids.
Plant J.
|
