CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.120.20
Functional Family

Enzyme Information

3.4.22.28
Picornain 3C.
based on mapping to UniProt P08617
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
-!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.
3.6.1.15
Nucleoside-triphosphate phosphatase.
based on mapping to UniProt P08617
NTP + H(2)O = NDP + phosphate.
-!- The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. -!- Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD. -!- The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt P08617
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.

UniProtKB Entries (2)

P08617
POLG_HAVHM
Human hepatitis A virus Hu/Australia/HM175/1976
Genome polyprotein
Q8QXR6
Q8QXR6_9PICO
Hepatovirus A
Viral protein 1

PDB Structure

PDB 4QPG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Hepatitis A virus and the origins of picornaviruses.
Wang, X., Ren, J., Gao, Q., Hu, Z., Sun, Y., Li, X., Rowlands, D.J., Yin, W., Wang, J., Stuart, D.I., Rao, Z., Fry, E.E.
Nature