CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family |
Enzyme Information
| 2.1.1.281 |
Phenylpyruvate C(3)-methyltransferase.
based on mapping to UniProt Q643C8
S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate.
-!- The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)- beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
|
UniProtKB Entries (1)
| Q643C8 |
MPPJ_STRHY
Streptomyces hygroscopicus
Phenylpyruvate C(3)-methyltransferase
|
PDB Structure
| PDB | 4M71 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase
Acta Crystallogr.,Sect.D
|
