CATH Domain 4hf2B00

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CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.10	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Domain Context

CATH Clusters

Superfamily	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family	HTH-type transcriptional regulator IscR

Enzyme Information

UniProtKB Entries (1)

ISCR_ECOLI

Escherichia coli K-12

HTH-type transcriptional regulator IscR

PDB Structure

PDB	4HF2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity. Rajagopalan, S., Teter, S.J., Zwart, P.H., Brennan, R.G., Phillips, K.J., Kiley, P.J. Nat.Struct.Mol.Biol.