CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydropteroate synthase-like
Functional Family 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

Enzyme Information

1.17.7.3
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin).
based on mapping to UniProt O67496
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H(2)O + oxidized flavodoxin = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin.
-!- Forms part of an alternative non-mevalonate pathway for isoprenoid biosynthesis that is found in most bacteria. -!- Plants and cyanobacteria have a similar enzyme that utilizes ferredoxin rather than flavodoxin (cf. EC 1.17.7.1).

UniProtKB Entries (1)

O67496
ISPG_AQUAE
Aquifex aeolicus VF5
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)

PDB Structure

PDB 3NOY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Biosynthesis of isoprenoids: crystal structure of the [4Fe-4S] cluster protein IspG.
Lee, M., Grawert, T., Quitterer, F., Rohdich, F., Eppinger, J., Eisenreich, W., Bacher, A., Groll, M.
J.Mol.Biol.