CATH Classification

Domain Context

CATH Clusters

Superfamily DHBP synthase
Functional Family 3,4-dihydroxy-2-butanone 4-phosphate synthase

Enzyme Information

4.1.99.12
3,4-dihydroxy-2-butanone-4-phosphate synthase.
based on mapping to UniProt P66032
D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate.
-!- The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5. -!- The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.

UniProtKB Entries (1)

P66032
RIBB_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
3,4-dihydroxy-2-butanone 4-phosphate synthase

PDB Structure

PDB 3LRJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potential anti-bacterial drug target: structural characterization of 3,4-dihydroxy-2-butanone-4-phosphate synthase from Salmonella typhimurium LT2.
Kumar, P., Singh, M., Gautam, R., Karthikeyan, S.
Proteins