CATH Domain 3khuD02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	1.20.5.100	Cytochrome c1, transmembrane anchor, C-terminal

Domain Context

CATH Clusters

Superfamily	Cytochrome c1, transmembrane anchor, C-terminal
Functional Family	UDP-glucose 6-dehydrogenase

Enzyme Information

1.1.1.22

UDP-glucose 6-dehydrogenase.

based on mapping to UniProt O60701

UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.

-!- Also acts on UDP-2-deoxyglucose.

UniProtKB Entries (1)

UGDH_HUMAN

Homo sapiens

UDP-glucose 6-dehydrogenase

PDB Structure

PDB	3KHU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates. Egger, S., Chaikuad, A., Klimacek, M., Kavanagh, K.L., Oppermann, U., Nidetzky, B. J.Biol.Chem.