CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1280 | Alpha/beta knot |
|
3.40.1280.10 | SPOUT methyltransferase, trefoil knot domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.1280.10 |
| Functional Family |
Enzyme Information
| 2.1.1.230 |
23S rRNA (adenosine(1067)-2'-O)-methyltransferase.
based on mapping to UniProt P18644
S-adenosyl-L-methionine + adenosine(1067) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methyladenosine(1067) in 23S rRNA.
-!- The methylase that is responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton. -!- Formerly EC 2.1.1.66.
|
UniProtKB Entries (1)
| P18644 |
TSNR_STRAJ
Streptomyces azureus
23S rRNA (adenosine(1067)-2'-O)-methyltransferase
|
PDB Structure
| PDB | 3GYQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the thiostrepton-resistance methyltransferase-S-adenosyl-L-methionine complex and its interaction with ribosomal RNA
J.Biol.Chem.
|