CATH Classification

Domain Context

CATH Clusters

Functional Family

Enzyme Information
DNA-formamidopyrimidine glycosylase.
based on mapping to UniProt Q5UQ00
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.
-!- May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. -!- Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt Q5UQ00
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC

UniProtKB Entries (1)

Acanthamoeba polyphaga mimivirus
Probable formamidopyrimidine-DNA glycosylase

PDB Structure

PDB 3A42
External Links
Primary Citation
Structural Characterization of a Viral NEIL1 Ortholog Unliganded and Bound to Abasic Site-containing DNA
Imamura, K., Wallace, S.S., Doublie, S.