CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Deoxynucleoside kinase

Enzyme Information

2.7.1.145
Deoxynucleoside kinase.
based on mapping to UniProt Q9XZT6
ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate.
-!- The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases (EC 2.7.1.76 and EC 2.7.1.113) in its broad specificity for all four common 2'-deoxyribonucleosides.

UniProtKB Entries (1)

Q9XZT6
DNK_DROME
Drosophila melanogaster
Deoxynucleoside kinase

PDB Structure

PDB 2VP6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Studies of Nucleoside Analog and Feedback Inhibitor Binding to Drosophila Melanogaster Multisubstrate Deoxyribonucleoside Kinase.
Mikkelsen, N.E., Munch-Petersen, B., Eklund, H.
FEBS J.