CATH Domain 2jaiB00

Level	CATH Code	Description
	3	Alpha Beta
	3.75	5-stranded Propeller
	3.75.10	L-arginine/glycine Amidinotransferase; Chain A
	3.75.10.10	L-arginine/glycine Amidinotransferase; Chain A

Superfamily	L-arginine/glycine Amidinotransferase; Chain A
Functional Family	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

3.5.3.18

Dimethylargininase.

based on mapping to UniProt O94760

N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.

-!- Also acts on N(omega)-methyl-L-arginine.

DDAH1_HUMAN

Homo sapiens

N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

PDB	2JAI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Disruption of methylarginine metabolism impairs vascular homeostasis. Leiper, J., Nandi, M., Torondel, B., Murray-Rust, J., Malaki, M., O'Hara, B., Rossiter, S., Anthony, S., Madhani, M., Selwood, D., Smith, C., Wojciak-Stothard, B., Rudiger, A., Stidwill, R., McDonald, N.Q., Vallance, P. Nat. Med.