CATH Domain 2g9xC01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P24941

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (2)

P30274	CCNA2_BOVIN Bos taurus Cyclin-A2
P24941	CDK2_HUMAN Homo sapiens Cyclin-dependent kinase 2

PDB Structure

PDB	2G9X
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination. Griffin, R.J., Henderson, A., Curtin, N.J., Echalier, A., Endicott, J.A., Hardcastle, I.R., Newell, D.R., Noble, M.E., Wang, L.Z., Golding, B.T. J.Am.Chem.Soc.