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1 keywords

CATH Domain 2bkkC02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.1200 Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2
Homologous Superfamily 3.90.1200.10 Aminoglycoside phosphotransferase (APH), C-terminal lobe

Domain Context

CATH Clusters

Superfamily 3.90.1200.10
Functional Family

Enzyme Information

2.7.1.95
Kanamycin kinase.
based on mapping to UniProt P0A3Y5
ATP + kanamycin = ADP + kanamycin 3'-phosphate.
-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.

UniProtKB Entries (1)

P0A3Y5
KKA3_ENTFL
Enterococcus faecalis
Aminoglycoside 3'-phosphotransferase

PDB Structure

PDB 2BKK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein
Kohl, A., Amstutz, P., Parizek, P., Binz, H.K., Briand, C., Capitani, G., Forrer, P., Pluckthun, A., Grutter, M.G.
Structure
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