CATH Classification

Domain Context

CATH Clusters

Superfamily Gamma-glutamyl cyclotransferase-like
Functional Family Gamma-glutamylaminecyclotransferase A

Enzyme Information

4.3.2.8
Gamma-glutamylamine cyclotransferase.
based on mapping to UniProt Q923B0
Epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline.
-!- The enzyme, found in vertebrates, has no activity toward alpha- (gamma-L-glutamyl)-L-amino acids (cf. EC 4.3.2.9). -!- The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.

UniProtKB Entries (1)

Q923B0
GGACT_MOUSE
Mus musculus
Gamma-glutamylaminecyclotransferase

PDB Structure

PDB
External Links
Method
Organism
Primary Citation
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