CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.250 | Oxidized Rhodanese; domain 1 |
|
3.40.250.10 | Rhodanese-like domain |
Domain Context
CATH Clusters
| Superfamily | Rhodanese-like domain |
| Functional Family | Dual-specificity phosphatase CDC25 |
Enzyme Information
| 3.1.3.48 |
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q8GY31
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
|
| 1.20.4.1 |
Arsenate reductase (glutaredoxin).
based on mapping to UniProt Q8GY31
Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H(2)O.
-!- A molybdoenzyme. -!- The enzyme is part of a system for detoxifying arsenate. -!- Although the arsenite formed is more toxic than arsenate, it can be extruded from some bacteria by EC 7.3.2.7; in other organisms, arsenite can be methylated by EC 2.1.1.137 in a pathway that produces non-toxic organoarsenical compounds (cf. EC 1.20.4.4). -!- Formerly EC 1.97.1.5.
|
UniProtKB Entries (1)
| Q8GY31 |
CDC25_ARATH
Arabidopsis thaliana
Dual specificity phosphatase Cdc25
|
PDB Structure
| PDB | 1T3K |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana.
Proc.Natl.Acad.Sci.Usa
|