CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | Double-stranded RNA-specific adenosine deaminase |
Enzyme Information
| 3.5.4.37 |
Double-stranded RNA adenine deaminase.
based on mapping to UniProt P55265
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.
|
UniProtKB Entries (1)
| P55265 |
DSRAD_HUMAN
Homo sapiens
Double-stranded RNA-specific adenosine deaminase
|
PDB Structure
| PDB | 1QGP |
| External Links | |
| Method | SOLUTION NMR |
| Organism | Escherichia |
| Primary Citation |
The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.
Proc.Natl.Acad.Sci.USA
|