CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Collagenase 3

Enzyme Information

3.4.24.34
Neutrophil collagenase.
based on mapping to UniProt P22894
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
-!- Similar to interstitial collagenase in specificity. -!- Stored in the specific granules of neutrophil leukocytes. -!- Belongs to peptidase family M10B.

UniProtKB Entries (1)

P22894
MMP8_HUMAN
Homo sapiens
Neutrophil collagenase

PDB Structure

PDB 1I73
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design.
Gavuzzo, E., Pochetti, G., Mazza, F., Gallina, C., Gorini, B., D'Alessio, S., Pieper, M., Tschesche, H., Tucker, P.A.
J.Med.Chem.