×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

1 keywords

CATH Domain 1g6gA00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.200 Tumour Suppressor Smad4
Homologous Superfamily 2.60.200.20  

Domain Context

CATH Clusters

Superfamily 2.60.200.20
Functional Family

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P22216
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P22216
RAD53_YEAST
Saccharomyces cerevisiae S288C
Serine/threonine-protein kinase RAD53

PDB Structure

PDB 1G6G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms.
Durocher, D., Taylor, I.A., Sarbassova, D., Haire, L.F., Westcott, S.L., Jackson, S.P., Smerdon, S.J., Yaffe, M.B.
Mol.Cell
CATH-Gene3D is a Global Biodata Core Resource Learn more...