CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase A1

Enzyme Information

5.3.3.-
Transposing C=C bonds.
based on mapping to UniProt P00502
2.5.1.18
Glutathione transferase.
based on mapping to UniProt P00502
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
1.11.1.-
Peroxidases.
based on mapping to UniProt P00502

UniProtKB Entries (1)

P00502
GSTA1_RAT
Rattus norvegicus
Glutathione S-transferase alpha-1

PDB Structure

PDB 1EV9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Localization of the C-terminus of rat glutathione S-transferase A1-1: crystal structure of mutants W21F and W21F/F220Y.
Adman, E.T., Le Trong, I., Stenkamp, R.E., Nieslanik, B.S., Dietze, E.C., Tai, G., Ibarra, C., Atkins, W.M.
Proteins