The name of this superfamily has been modified since the most recent official CATH+ release (current). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 622: ATP-binding cassette sub-family G member 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9UNQ0 (/IPI) Q9UNQ0 (/IPI)
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2 Q9UNQ0 (/IDA) Q9UNQ0 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q9UNQ0 (/IPI) Q9UNQ0 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9UNQ0 (/IDA) Q9UNQ0 (/IDA)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
1 Q80W57 (/IPI)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
1 Q7TMS5 (/ISO)
ATPase-coupled xenobiotic transmembrane transporter activity GO:0008559
Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
1 Q7TMS5 (/ISO)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 A8IJF9 (/IDA)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
1 Q80W57 (/TAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q7TMS5 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q7TMS5 (/ISO)
Amide transmembrane transporter activity GO:0042887
Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other.
1 Q7TMS5 (/ISO)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
1 Q80W57 (/IDA)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
1 Q7TMS5 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
2 Q9UNQ0 (/TAS) Q9UNQ0 (/TAS)
Urate metabolic process GO:0046415
The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.
2 Q9UNQ0 (/IMP) Q9UNQ0 (/IMP)
Cellular detoxification GO:1990748
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
2 Q9UNQ0 (/IDA) Q9UNQ0 (/IDA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q80W57 (/IEP)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
1 Q80W57 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 A8IJF9 (/IDA)
Urate transport GO:0015747
The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q80W57 (/IMP)
Urate transport GO:0015747
The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q7TMS5 (/ISO)
Drug transport GO:0015893
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q80W57 (/IDA)
Drug transport GO:0015893
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q7TMS5 (/ISO)
Response to insecticide GO:0017085
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.
1 A8IJF9 (/IDA)
Glucuronoside metabolic process GO:0019389
The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate.
1 Q80W57 (/IMP)
Glucuronoside metabolic process GO:0019389
The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate.
1 Q7TMS5 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q80W57 (/IEP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 Q80W57 (/IEP)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 Q80W57 (/IEP)
Urate metabolic process GO:0046415
The chemical reactions and pathways involving urate, the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals.
1 Q7TMS5 (/ISO)
Drug export GO:0046618
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
1 Q80W57 (/IMP)
Drug export GO:0046618
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle.
1 Q7TMS5 (/ISO)
Response to organophosphorus GO:0046683
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors.
1 A8IJF9 (/IDA)
Response to folic acid GO:0051593
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.
1 Q80W57 (/IEP)
Embryonic process involved in female pregnancy GO:0060136
A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.
1 Q80W57 (/IDA)
Embryonic process involved in female pregnancy GO:0060136
A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.
1 Q7TMS5 (/ISO)
Cellular response to estradiol stimulus GO:0071392
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q80W57 (/IEP)
Cellular response to dexamethasone stimulus GO:0071549
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
1 Q80W57 (/IEP)
Urate salt excretion GO:0097744
The elimination by an organism of urate salt or uric acid.
1 Q80W57 (/IEP)
Negative regulation of intestinal absorption GO:1904479
Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption.
1 Q80W57 (/IMP)
Negative regulation of intestinal absorption GO:1904479
Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption.
1 Q7TMS5 (/ISO)
Response to 2,3,7,8-tetrachlorodibenzodioxine GO:1904612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus.
1 Q80W57 (/IEP)
Cellular detoxification GO:1990748
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
1 Q7TMS5 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 A0A024RDD4 (/IDA) A0A024RDD4 (/IDA) A8IJF9 (/IDA) Q80W57 (/IDA) Q9UNQ0 (/IDA) Q9UNQ0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 A0A024RDD4 (/IDA) A0A024RDD4 (/IDA) Q80W57 (/IDA) Q9UNQ0 (/IDA) Q9UNQ0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q7TMS5 (/TAS) Q9UNQ0 (/TAS) Q9UNQ0 (/TAS)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
3 A0A0J9YJL0 (/IDA) A0A0R4IUY7 (/IDA) Q2Q447 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q7TMS5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7TMS5 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q80W57 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q7TMS5 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q80W57 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q7TMS5 (/ISO)
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