The name of this superfamily has been modified since the most recent official CATH+ release (current). At the point of the last release, this superfamily was named:
"P-loop containing nucleotide triphosphate hydrolases
".
FunFam 3987: RAD50 homolog uvs-6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA helicase activity GO:0003678
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
|
1 | Q9UTJ8 (/ISO) |
|
Double-stranded telomeric DNA binding GO:0003691
Interacting selectively and non-covalently with double-stranded telomere-associated DNA.
|
1 | Q9UTJ8 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q9UTJ8 (/ISM) |
|
Single-stranded telomeric DNA binding GO:0043047
Interacting selectively and non-covalently with single-stranded telomere-associated DNA.
|
1 | Q9UTJ8 (/ISO) |
|
DNA end binding GO:0045027
Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs).
|
1 | Q9UTJ8 (/EXP) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Telomere maintenance via recombination GO:0000722
Any recombinational process that contributes to the maintenance of proper telomeric length.
|
1 | Q9UTJ8 (/IGI) |
|
Telomere maintenance GO:0000723
Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.
|
1 | Q9UTJ8 (/IGI) |
|
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
1 | Q9UTJ8 (/IC) |
|
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
|
1 | Q9UTJ8 (/IC) |
|
Regulation of reciprocal meiotic recombination GO:0010520
Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.
|
1 | Q9UTJ8 (/IMP) |
|
Gene conversion at mating-type locus, DNA double-strand break processing GO:0031292
The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang.
|
1 | Q9UTJ8 (/IMP) |
|
Intra-S DNA damage checkpoint GO:0031573
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
|
1 | Q9UTJ8 (/IMP) |
|
Meiotic DNA double-strand break formation GO:0042138
The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.
|
1 | Q9UTJ8 (/IMP) |
|
DNA damage response, detection of DNA damage GO:0042769
The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.
|
1 | Q9UTJ8 (/IC) |
|
Signal transduction involved in DNA damage checkpoint GO:0072422
A signal transduction process that contributes to a DNA damage checkpoint.
|
1 | Q9UTJ8 (/IC) |
|
DNA strand resection involved in replication fork processing GO:0110025
The 5' to 3' exonucleolytic resection of DNA at the site of a stalled replication fork that contributes to replication fork processing.
|
1 | Q9UTJ8 (/IMP) |
|
Mitotic recombination involved in replication fork processing GO:1903211
Any mitotic recombination that is involved in replication fork processing.
|
1 | Q9UTJ8 (/IMP) |
|
Mitotic recombination-dependent replication fork processing GO:1990426
Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart.
|
1 | Q9UTJ8 (/IMP) |
|
Meiotic DNA double-strand break clipping GO:1990898
The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP).
|
1 | Q9UTJ8 (/IMP) |
|
Double-strand break repair involved in meiotic recombination GO:1990918
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination.
|
1 | Q9UTJ8 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | Q9UTJ8 (/IC) |
|
Mre11 complex GO:0030870
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
|
1 | Q9UTJ8 (/IPI) |
|
Site of double-strand break GO:0035861
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
|
1 | Q9UTJ8 (/IDA) |
