The name of this superfamily has been modified since the most recent official CATH+ release (current). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2481: MIP14774p

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
4 F0JAF7 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
4 F0JAF7 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
4 F0JAF7 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS)
Rab protein signal transduction GO:0032482
A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.
4 F0JAF7 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
4 F0JAF7 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
4 F0JAF7 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Synaptic vesicle endosomal processing GO:0099532
The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
4 F0JAF7 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Synaptic vesicle endosomal processing GO:0099532
The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles.
4 F0JAF7 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Exosomal secretion GO:1990182
The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
4 F0JAF7 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Polarity specification of proximal/distal axis GO:0010085
Any process resulting in the establishment of polarity along the proximal/distal axis.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Lumen formation, open tracheal system GO:0035149
Creation of the central hole of a tube in an open tracheal system through which gases flow.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Apical protein localization GO:0045176
Any process in which a protein is transported to, or maintained in, apical regions of the cell.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Plasma membrane to endosome transport GO:0048227
Transport of a vesicle from the plasma membrane to the endosome.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Cytoskeletal rearrangement involved in phagocytosis, engulfment GO:0060097
The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Endosome to plasma membrane protein transport GO:0099638
The directed movement of proteins from the endosome to the plasma membrane in transport vesicles.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Positive regulation of apical constriction involved in ventral furrow formation GO:0110074
Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Positive regulation of establishment of protein localization GO:1904951
Any process that activates or increases the frequency, rate or extent of establishment of protein localization.
3 Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 F0JAF7 (/HDA) Q9W5X0 (/HDA) Q9W5X0 (/HDA) Q9W5X0 (/HDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
4 F0JAF7 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
4 F0JAF7 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP) Q9W5X0 (/IMP)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
4 F0JAF7 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS) Q9W5X0 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
4 F0JAF7 (/HDA) Q9W5X0 (/HDA) Q9W5X0 (/HDA) Q9W5X0 (/HDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 F0JAF7 (/HDA) Q9W5X0 (/HDA) Q9W5X0 (/HDA) Q9W5X0 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
3 Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
3 Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Anterior cell cortex GO:0061802
The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis.
3 Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Posterior cell cortex GO:0061803
The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis.
3 Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Endosome to plasma membrane transport vesicle GO:0070381
A transport vesicle that mediates transport from the endosome to the plasma membrane, and fuses with the plasma membrane to deliver lipids and membrane proteins to the plasma membrane and to release various cargo molecules, such as proteins or hormones, by exocytosis.
3 Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
Cytoplasmic side of apical plasma membrane GO:0098592
The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm.
3 Q9W5X0 (/IDA) Q9W5X0 (/IDA) Q9W5X0 (/IDA)
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