The name of this superfamily has been modified since the most recent official CATH+ release (current). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1282: RAB17, member RAS oncogene family

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P35292 (/IPI) P35292 (/IPI) Q9H0T7 (/IPI) Q9H0T7 (/IPI)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 Q9H0T7 (/IDA) Q9H0T7 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 P35292 (/ISO) P35292 (/ISO)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
2 Q9H0T7 (/IDA) Q9H0T7 (/IDA)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
2 P35292 (/ISO) P35292 (/ISO)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
2 P35292 (/ISS) P35292 (/ISS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415
The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
2 P35292 (/IMP) P35292 (/IMP)
Immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor GO:0002415
The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Establishment of melanosome localization GO:0032401
The directed movement of a melanosome to a specific location.
2 P35292 (/IMP) P35292 (/IMP)
Establishment of melanosome localization GO:0032401
The directed movement of a melanosome to a specific location.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Melanosome transport GO:0032402
The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P35292 (/IMP) P35292 (/IMP)
Melanosome transport GO:0032402
The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
2 P35292 (/IMP) P35292 (/IMP)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Transcytosis GO:0045056
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
2 P35292 (/IMP) P35292 (/IMP)
Transcytosis GO:0045056
The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
2 P35292 (/IMP) P35292 (/IMP)
Filopodium assembly GO:0046847
The assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
2 P35292 (/IMP) P35292 (/IMP)
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Regulation of filopodium assembly GO:0051489
Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
2 P35292 (/IMP) P35292 (/IMP)
Regulation of filopodium assembly GO:0051489
Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
2 P35292 (/IMP) P35292 (/IMP)
Regulation of synapse assembly GO:0051963
Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
2 Q9H0T7 (/IMP) Q9H0T7 (/IMP)
Cilium assembly GO:0060271
The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
2 P35292 (/ISO) P35292 (/ISO)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
2 Q9H0T7 (/IDA) Q9H0T7 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P35292 (/IDA) P35292 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P35292 (/IDA) P35292 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
2 Q9H0T7 (/IDA) Q9H0T7 (/IDA)
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
2 P35292 (/ISO) P35292 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P35292 (/IDA) P35292 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
2 P35292 (/IDA) P35292 (/IDA)
Melanosome GO:0042470
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P35292 (/IDA) P35292 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
2 P35292 (/IDA) P35292 (/IDA)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
2 P35292 (/IDA) P35292 (/IDA)
Recycling endosome membrane GO:0055038
The lipid bilayer surrounding a recycling endosome.
2 Q9H0T7 (/ISS) Q9H0T7 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 Q9H0T7 (/HDA) Q9H0T7 (/HDA)
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